A collaborative study drawing from two IMP labs and led by IMP-alumnus Mark Petronczki, now at Boehringer Ingelheim RCV, demonstrates a unique Achilles heel of tumors carrying a frequent mutation in the cohesin-molecule. Targeting this vulnerability by inducing synthetic lethality opens a promising way for future therapies. The study was published in the online-journal eLife on 10 July 2017.
Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy. At this point, the affected patients usually only have a few months to live. The reason for this was hitherto unknown. Researchers at MedUni Vienna, led by Gerhard Hamilton (Department of Surgery), have now discovered that circulating tumour cells combine, making previously chemo-sensitive cells into chemo-resistant cell complexes.
Children in Power – in the words of the all-time hit by Herbert Grönemeyer, it is the kids who are "ruling" for a week at the Medical University of Vienna. Today MedUni Vienna's Vice Rector for Clinical Matters, Oswald Wagner, opened KinderuniMedizin [Children’s University - Medicine], which is celebrating its 15th anniversary this year and offering a total of 6,000 student places in 87 classes focusing on the theme of "Saving lives, helping people". The opening lecture entitled "What exactly is epilepsy?" was given by Helmut Kubista from MedUni Vienna's Division of Neurophysiology and Neuropharmacology
Some newly born piglets shiver even when they are kept warm. So-called “shaking piglets” have symptoms that resemble those of the classical swine fever, with extensive damage to the brain and the spinal cord. The viral origin of the disease was clarified only recently with the discovery in Europe and the USA of an atypical porcine pestivirus. Researchers at the Vetmeduni Vienna have now discovered a further new virus in shaking piglets on an Austrian farm. The pathogenic agent is related to the Australian Bungowannah virus and more distantly to the classical swine fewer virus. Because of the symptoms it causes, the new virus is termed LINDA virus (Lateral shaking Inducing NeuroDegenerative Agent). Its discovery was recently announced in the journal “Emerging infectious diseases”.
This is a momentous day for any startup, but for a team on a mission it’s even greater. Today we’re proud to announce that we’re joining the Roche family to help create an open digital diabetes ecosystem that revolves entirely around people with diabetes.
The ability to verify where data has come from (provenance) is becoming increasingly important in the context of the growing challenges posed by digitalization. Tiani Spirit has been named one of the four winners of the “Oh the Places Data Goes: Health Data Provenance Challenge” for its blockchain solution based on the Hyperledger platform.
The companies ABF Pharmaceutical Services GmbH (Vienna), LPU Labor für Pharma- und Umweltanalytik GmbH (located in Martinsried and Gräfelfing), Phytos Labor für Analytik von Arzneimitteln GmbH & Co. KG (Neu-Ulm), and Pharmacelsus GmbH (Saarbrücken), all of which are members of the GBA Laboratory Group will merge. The upcoming rebranding which will occur on August 31st, 2017.
Bornaviruses cause a lethal form of encephalitis, called Borna disease, among horses and sheep. To date there have been only a few reported cases in Austria. Recently, however, four horses were afflicted in the same area of Upper Austria within just two years. Tests conducted on local shrews, the only known reservoir host for the virus, confirmed the suspicion of a local viral reservoir. A large proportion of the small mammals investigated by the researchers from Vetmeduni Vienna tested positive for Bornaviruses, which were revealed to be genetically distinct from strains found in neighbouring regions such as Bavaria. The study, conducted in cooperation with the Austrian Agency for Health and Food Safety (AGES) and local veterinarians, and published in the journal Emerging Microbes & Infections, documents this rare outbreak of Borna disease in a new endemic area in Austria.
The islets of Langerhans in the human pancreas produce and release insulin to regulate blood glucose levels. Insulin, which is specifically produced in -cells, serves to prompt cells to take up glucose circulating in blood. Thus, insulin release lowers the level of glucose in blood. In diabetes, this cycle is disrupted by the premature death of -cells. Working with an international team of researchers, Katarzyna Malenczyk from the Department of Molecular Neurosciences at MedUni Vienna's Center for Brain Research showed in the study published in the EMBO Journal today that the loss of a key protein, secretagogin, triggers the death of -cells and, conversely, that these cells can be protected by increasing the amount of this protein in those suffering from diabetes.